New research indicates that people who discontinue popular weight-loss injections like semaglutide or tirzepatide can put back on lost weight far faster than those who halt conventional diet and exercise plans.
Published data in a prominent medical journal shows that while overweight individuals often shed substantial amounts of their total mass while on the medication, the weight comes back at an estimated rate of nearly a kilo each month once they quit.
"Users purchasing these medications need to be informed of the danger of rapid rebound weight gain when the therapy concludes," stated lead investigator Dr. Susan Jebb.
Such speed of regain suggests a return to starting weight in about one and a half years.
Weighing Approaches
The study, which reviewed 37 of trials involving thousands of patients, compared the results of GLP-1 agonists with conventional dieting.
Researchers emphasize that individuals who lose weight through lifestyle changes alone usually experience a more gradual weight regain—perhaps 100 grams monthly—post-intervention.
The Reason for the Quick Rebound
Experts propose the way of the jabs accounts for the accelerated regain.
These medications mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Artificially providing the hormone levels far above than the body's typical production might result in the system to produce less of its endogenous hormone, and may also reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication leads to hunger is uncontrolled, making excessive eating far more likely."
A Chronic Condition?
Health authorities suggest the injections for people with weight-linked health risks, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, due to the high risk of relapse, the treatment is often long-term.
This view is echoed by pharmaceutical companies, who note that the results "underscore the persistent nature of obesity," comparing it to managing conditions like high blood pressure.
Patient Accounts
Individuals who have discontinued the jabs describe a sudden return of cravings.
"It was like a trigger that goes on and I was suddenly starving," said one woman.
The struggle is compounded if individuals have not developed sustainable lifestyle or habit modifications during therapy.
Widespread Interest
Figures suggest that millions of people in the UK have tried weight-loss jabs in the past year, with interest continuing to grow.
- Use is more common among women compared to males.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Ultimately, researchers caution that while the jabs are potent agents for shedding pounds, they are not a permanent cure and long-term success likely depends on combined lifestyle support.